Generic Clonidine (Clonidine )
Clonidine
Clonidine is an alpha-agonist hypotensive agent to decrease blood pressure employed alone or in combination with other antihypertensive drugs.
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Product Description
A further rise in the plasma levels will not enhance the antihypertensive effect. The tablet is usually taken two times a day at evenly spaced intervals. Substance Abuse. Clonidine is also used to treat high blood pressure in both children and adults. Catapres slide 8 of 35, Catapres. We do know that clonidine works in the part of the brain that helps regulate behavior, attention, and how we express emotion. The duration of action varies from hours, the duration of action being longer in the milder hypertensives. Substances which raise blood pressure or induce a sodium and water retaining effect such as nonsteroidal anti-inflammatory drugs can reduce the therapeutic effect of clonidine. J Med Toxicol. This book is distributed under the terms of the Creative Commons Attribution 4. Clonidine has also been effective in managing withdrawal symptoms in the treatment of alcoholism and opiate dependency. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Incompatibilities were either not assessed or not identified as part of the registration of this medicine. Always seek the advice of a Clknidine or other qualified medical professional with any questions you may have regarding medications or medical conditions. Clonidine is used in addition to non-medication Clomidine to manage ADHD symptoms. It has been shown to cross the blood-brain barrier in rats. Your use of the content provided in this service indicates that you have read, understood and agree to the End-User License Agreement, which can be accessed by End-User License Agreement, which can be accessed by clicking on this link. Overdosing with clonidine may cause sleepiness, dizziness, low blood pressure and slow heart rate. In: StatPearls [Internet]. Your pharmacist can provide more information about clonidine. Pharmacological therapies for management of opium withdrawal. Your doctor may occasionally change your dose to make sure you get the best results. J Knee Surg. This medicine is also available as a transdermal patch worn on the skin. Clonidine hydrochloride may potentiate the effects of alcohol, sedatives, hypnotics or other centrally active substances. You may need to use blood pressure medication for Clonjdine rest of your life. However, the effect Clonicine prescription drugs on body weight is complex. Do not use two forms of clonidine at the same time. Current Psychiatry Reports. Following Cloniidine discontinuation of clonidine hydrochloride after prolonged treatment Cponidine high doses, restlessness, palpitations, rapid rise in blood pressure, nervousness, tremor, headache or nausea have been reported. High blood pressure may also increase the risk for heart attacks. Clinical trials. Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. Ask your doctor or pharmacist to teach you how to take your pulse. As the effect on the newborn is not known, infants born to mothers being treated with clonidine hydrochloride should not be breast fed. Your use of the content provided in this service indicates that you have read, understood and agree to the End-User License Agreement, which can be accessed by End-User License Agreement, which can be accessed by clicking on this link. What should I discuss with my healthcare provider before taking clonidine? Take the missed dose as soon as you remember it. Anesth Pain Med. Migraine prophylaxis. Menopausal flushing. Clonidine may be effective for lowering blood pressure in people with resistant hypertension. There are no known problems associated with long term use of clonidine.

Clonidine - opinion

Always tell your alcohol if you have appointments to Clonidine medications. Tropical Pharmacokinetics. You Clonidinne need robust amounts of your primary, or you may need to take only suppositories. This cinema is indicated to the brain's special kind of PFC wars by the locus ceruleus LCwhich causes norepinephrine into the PFC. Do not cure your next dose or take more than what is contraindicated. This binding has Clonidine sympatholytic effect, suppresses release of norepinephrineATPrenin, and neuropeptide Y which if released would increase vascular resistance. American Clonidihe of Health-System Pharmacists. If you Clonidune light-headed, dizzy or faint, get up slowly when getting out of bed or standing up. Med Lett Drugs Ther. After being ingested, clonidine is absorbed into the blood stream rapidly and nearly completely, with peak concentrations in human plasma occurring within 60—90 minutes. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or combination is safe, effective or appropriate for any given patient. Clonidine passes the placental barrier, and may lower the heart rate of the foetus. Get Involved Share Your Story. It is soluble in ethanol, slightly soluble in chloroform and practically insoluble in ether. This information is being provided as a community outreach effort of the College of Psychiatric and Neurologic Pharmacists. Follow all directions on your prescription label. Your doctor will also want to know, before starting you on clonidine, if you have any of these other conditions:. Before taking clonidine, tell your doctor and Clonidine if you are allergic to clonidine, any of its CClonidine, clonidine patches, or any other medications. We rounded up our favorite products to help you…. Drugs Clonodine ADHD. Some of the common side effects based on FDA reports include: Common Reactions tend to resolve with continued therapy Abdominal pain. A: Drugs can cause weight gain in several different ways. Drug information contained herein may be time sensitive. The authors of the report wrote, "Clonidine reportedly boosts and extends the opioid-related 'high' and reduces the amount of psychoactive drug needed. About Mental Illness Treatments. It works in the brain to change some of the nerve impulses. You usually take clonidine twice a day at about the same times. Molecular formula: C 9 H 9 N 3 Cl 2. Anesth Pain Med. Overdose symptoms may include dangerously high blood pressure severe headache, pounding in your neck or ears, nosebleed, anxiety, chest pain, shortness of breath followed by low blood pressure feeling like you might pass out. Weekly news roundup. All grades of essential hypertension. Do not be alarmed by the following list of side effects. Dihydroergotamine Ergotamine Methysergide Lisuride. If after two weeks there has been no remission, increase to 50 micrograms twice daily. Use in the elderly. Before Clonidins clonidine, tell your doctor and pharmacist if Clonirine are allergic to clonidine, any of its ingredients, clonidine patches, or any other medications. Do not drive a car or Clonidihe machinery until you know how this medication affects you. Effects on laboratory tests. Q: Why does the drug clonidine seem to be the drug of choice by doctors in eastern Kentucky? Get emergency medical help if you have signs of an allergic reaction to clonidine : hives; difficult breathing; swelling of your face, lips, tongue, or throat. If you take the tablets out of the blister strip they may not keep well. Your Journey Individuals with Mental Illness. Although a transient rise in blood sugar has been noted occasionally in humans treated with clonidine hydrochloride, which may be due to a pharmacologic alpha-adrenomimetic effect of the drug, no case of induced diabetes mellitus due to clonidine hydrochloride has been reported. Ethanol selectively counteracts hypotension evoked by central I 1 -imidazoline but not alpha2-adrenergic receptor activation in spontaneously hypertensive rats.

Common use

Clonidine maybe used orally or as patches applied to your skin, it treats high blood pressure. It acts changing concentration of certain chemicals in blood and stimulating alpha2-adrenoceptors in the brain stem that reduces transmission of a signal from brain to other areas in the body. Its action results in a decrease in peripheral resistance, renal vascular resistance, heart rate, and blood pressure.



Dosage and direction

Usually Clonidine is taken twice daily, dosage depends on individual blood pressure response of a patient. Do not use this drug if it was not prescribed to you by your physician. In case you use patches they should be applied to an area of hairless skin on the upper arm or torso, once every 7 days. When you change the patch for a new one, choose a different area of skin.



Precautions

Avoid drinking alcohol, be especially attentive if you need to drive or make any work which requires high concentration of attention.



Contraindications

Hypersensitivity to Clonidine or any component of the formulation. Contraindication may also include in patients with sick sinus syndrome, bradicardia, atrioventricular block (degree II and III). Cautiousness should be exercised in cases of acute myocardial infraction, Reino syndrome, endogenous depression kidney failure and others.



Possible side effect

Beside of signs of allergic reaction such as hives, difficulty breathing, swelling such side effects may appear: fast or pounding heartbeats, a very slow heart rate, swelling, rapid weight gain, confusion, hallucinations, fever, pale skin, urinating less than usual. If you experience them seek for immediate medical attention.



Drug interaction

Clonidine causes increase of sedative effect of barbiturates, narcotic pain relievers and alcohol. Certain antidepressants may diminish pharmaceutical effect of Clonidine. Kidney damage maybe caused by increased concentration of Cyclosporine when Clonidine is administered concurrently. Concomitant prescription of Clonidine with medications which lower heart rate (beta-blockers) should be done with cautiousness.



Missed dose

If you missed a dose take it as soon as you remember, but if it is almost time of your next dose, just skip the forgotten dose. Do not try to compensate a missed dose by taking an extra one.



Overdose

If you suspect that you took too much of Clonidine and your blood pressure first becomes too high (severe headache, blurred vision, buzzing in your ears, anxiety, confusion, chest pain) and then followed by low blood pressure (fainting, cold feeling, slow heart rate) seek for immediate medical attention.



Storage

Tablets and patches should be stored at room temperature 15-30 C (59-86 F) in a light- resistant container away from moisture.



Disclaimer

We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.

Antibiotics

Antibiotics is one of most prescribed group of medications. Antibiotics are antibacterial (antimicrobial agents) that kills bacteria(bactericidal) or stop the growth of the bacteria(bacteriostatic action).

Antibiotics are used to treat bacterial infections and are not indicated for the viral infections. Currently there is a big variety of antibiotics available. All the antibiotics are divided into two main groups according to the action mechanism:

  • Antibiotics with bactericidal action(penicillins, cephalosporins, aminoglycoside)
  • Antibacterial with bacteriostatic action(macrolides, tetracyclines)

Penicillins and cephalospororins are the most prescribed group of antibiotics. They belong to half-synthetic beta lactam antibiotics. These antibiotics work by inhibiting the enzymes responsible for the production of peptidoglycan. Peptidoglycan is a biopolimer that is a main structural component of the bacterial cell wall. The blockage of peptidoglycan synthesis leads to the lysis of the microorganisms.

Another group of preparations are aminoglycosides. However, these antibiotics are prescribed in rare cases. The most of aminoglycosides possesses nephrotoxicity, ototoxicity and cab cause neuromuscular blockage. Bactericidal action of aminoglycosides is related to the interfering with the synthesis of proteins on the ribisomes in the microbial cells. When aminoglycosides are used with penicillins and cephalosporins the sinergism against gram-positive and gram-negative microorganisms is observed.

Among all bacteriostatic antibiotics macrolides and tetracyclines are the most indicated groups. Therapeutic effect of macrolides is associated with inhibiting the synthesis of proteins on the ribosomes in the microbial cell. As usual macrolides exert bacteriostatic action, however in high amounts are able to exert bactericidal action on some microorganisms. Besides antibacterial action, some macrolides possesses immunomodulatory and anti-inflammatory action.

Another group of bacteriostatic antibiotics are used less frequently as many microorganisms became resistant to the this type of antibiotics. Bacteriostatic effect of the tetracyclines is associated with inhibiting the synthesis of proteins. Tetracycline are indicated in clamydia infections, rickettsial disease, some zoonosis, severe acne.

Antibiotics are indicated and used only in the cases of the bacteria is sensitive to the antibiotics. There some specific tests like antibiogram that will help to determine the right antibiotic and corresponding dose.