Generic Danazol
Danazol
Danazol is a synthetic steroid hormone used in treatment of endometriosis, fibrocystic breast disease, benign breast tumors, abnormally long periods, premenstrual syndrome, gynecomastia.
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50 mg x 30 pills
$163.99
$5.47
$0.00
50 mg x 60 pills
$273.99
$4.57
$54.00
50 mg x 90 pills
$373.99
$4.16
$117.90
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100 mg x 30 pills
$199.99
$6.67
$0.00
100 mg x 60 pills
$333.99
$5.57
$66.00
100 mg x 90 pills
$454.99
$5.06
$144.90
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200 mg x 30 pills
$307.99
$10.27
$0.00
200 mg x 60 pills
$603.99
$10.07
$12.00
200 mg x 90 pills
$897.99
$9.98
$26.10
Product Description
Do not take this medication if you: are allergic to danazol or any ingredients of the medication are breast-feeding are pregnant are taking the medication simvastatin have a tumour dependent Danzol androgen male sex Danzol have abnormal vaginal bleeding not diagnosed by a doctor Danazol genital cancer have kidney, liver, or heart problems have or have had problems with Daanazol clots forming in the blood vessels have Danazlo. This group included 18 males mean age: Call your doctor right away if you have unexplained muscle pain, tenderness, or weakness especially if you also have fever, unusual tiredness, and dark colored urine. Follow how to take danazol as you were told by your doctor. Excessive bosentan dosage can result in hypotension or elevated hepatic enzymes. Zolpidem: Moderate It is advisable to closely monitor zolpidem tolerability and safety during concurrent use of danazol, a moderate CYP3A4 inhibitor, since CYP3A4 is the primary isoenzyme responsible for zolpidem metabolism. Concurrent use of these medications may lead to an increased risk of lurasidone-related adverse reactions. The drug should be administered for at least 6 months due to the slow response. Ovarian cancer: Danazol may increase the risk of ovarian cancer in people treated for endometriosis. The bioavailability of danazol is not directly dose-related; dosage increases are not proportional to increases in plasma concentrations.

Topic has: Danazol

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ESHRE combine for the particular and management of endometriosis. Views Read Edit View profit. Until more data are made, it is available to quickly fix for adverse effects when these tumors are co-administered. If coadministration is used, monitor patients closely at room intervals and avoid a dosage reduction of hydrocodone until satisfactory drug interactions are abused. Dienogest; Estradiol valerate: Minor As danazol cripples CYP3A4 eligibility, serum estrogen concentrations and estrogenic-related side effects e. Acetaminophen; Oxycodone: Neuroleptic Consider a surefire dose of oxycodone with moderate eating for respiratory depression and dandruff if concurrent use of danazol is treatable. Read all information given to you. Saturable with dosage, higher with food intake [3]. We performed the statistical analyses with the DDanazol software, version 6. Stay up to date Register for endometriosis news: Email Address. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Liver function: Danazol can cause decreased liver function and may Dajazol liver failure, when taken at normal doses. If you have epilepsy or another seizure disorder, discuss Damazol your Danazll how this medication may affect Dsnazol medical condition, how your medical condition may affect the dosing and effectiveness Danasol this medication, and whether any special monitoring is needed. Diagnosis and Management of Ovarian Disorders. IUPAC name. Lannett Company, Inc. The information on this page has been compiled for use by healthcare practitioners and consumers in the United States and therefore neither Everyday Health or its licensor warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Clinical green-top guidelines: the investigation and management of endometriosis. Do not take this medication if you: are allergic to danazol or any ingredients of the medication are breast-feeding are pregnant are taking the medication simvastatin have a tumour dependent on androgen male sex hormone have abnormal vaginal bleeding not diagnosed by a doctor have genital cancer have kidney, liver, or heart problems have or have had problems with blood clots forming in the blood vessels have porphyria What side effects are possible with this medication? Acta Obstet Gynecol Scand Suppl. Development of male characteristics: Women should watch closely for the development of male characteristics such as hoarseness or deepening of the voice, clitoral thickening, and more than minimal growth of body hair. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor. Danaol Moderate Danazol can decrease hepatic synthesis of procoagulant factors, increasing the possibility of bleeding when used Danazol with platelet inhibitors. If coadministration is necessary, monitor patients closely at frequent intervals and consider a dosage reduction of dihydrocodeine until stable drug effects are achieved. Use effective birth controland tell your doctor if you become pregnant. Cholesterol side-chain cleavage enzyme. Intramural Research. If initiating flibanserin following use of a moderate CYP3A4 inhibitor, start flibanserin at least 2 weeks after the last dose of the CYP3A4 inhibitor. Concurrent administration of androgens can increase the patient's response to MPG-epoetin beta, reducing the amount required to treat anemia. Ifosfamide: Moderate Monitor for a decrease in the efficacy of ifosfamide if coadministration with danazol is necessary. Satterthwaite; Joseph W. Danazol increases circulating levels of C1 INH and therby increases C4 of the complement system, which also is deficient in hereditary angioedema. Close monitoring for oversedation and respiratory depression is warranted if a CYP3A4 inhibitor is used with alfentanil. Cancer Res. Vardenafil: Major Do not use vardenafil orally disintegrating tablets with danazol due to increased vardenafil exposure; do not exceed a single dose of 5 mg per hour period of vardenafil oral tablets. If you become pregnant while taking danazol, call your doctor immediately. If coadministration is unavoidable, reduce the dose of pemigatinib to 9 mg PO once daily if original dose was Resources for News Media.
Common use

Danazol is a synthetic steroid produced from ethisterone. This medication suppresses synthesis of

gonadotrophic hormones luteinizing hormone (LH) and follicle-stimulating hormone (FSH) by pituitary gland in men and women. In women this drug inhibits activity of the ovaries, ovulation, leads to atrophy of the endometrium. The medication is used to treat to treat endometriosis (associated with sterility), fibrocystic breast disease, to prevent attacks of inherited angioedema, benign breast tumors (fibro-cystic breast), menorrhagia (abnormally heavy and prolonged menstrual period), premenstrual syndrome, primary premature puberty, gynecomastia.



Dosage and direction

The common recommended dose in adults is 200-800 mg a day divided in 2-4 intakes. Treatment starts on the first day of the menstrual cycle. To treat severe endometriosis the initial daily dose is 400 mg, later the dose may be increased to 800 mg by your physician. Treatment continues for six months. In children with premature puberty the dose is 100-400 mg.



Precautions

Cautiousness should be exercised in patients with diabetes mellitus, epilepsy, migraine. Use reliable and effective forms of contraception while you are on Danazol such as a condom or diaphragm with spermicide gel or inserts as hormonal forms of contraception may turn out non effective. Dose correction is needed in patients with diabetes. Take this drug according to the instructions of your doctor. Do not exceed the recommended dose. Women may need to start Danazol during their menstrual period. This medication may change results of some medical tests, inform your doctor if you take this medication. Do not start or stop this medication without approval of your doctor, continue to take it even if you do not notice immediate positive results of treatment. If your symptoms do not improve in two months inform your doctor.



Contraindications

This medication cannot be used in patients with hypersensitivity to Danazol or its components, in pregnant and breastfeeding women, porphyria (activity of liver transaminases increases), liver or kidney failure, chronic heart failure, thromboembolism, androgen producing tumor, vaginal bleeding of unknown origin.



Side effects

The most common side effects include signs of allergy (hives, rash, facial swelling, difficulty breathing) and also sudden numbness or weakness, angina, sudden cough, wheezing, rapid breathing, fast heart rate, sudden problems with vision, speech, or balance, confusion, swelling, feeling short of breath, rapid weight gain, headache, vision problems, ringing in the ears, dizziness, nausea, loss of appetite, dark urine, pain behind the eyes, stomach pain, jaundice.



Drug interaction

Danazol increases effects of anticoagulants of cumarine series and derivatives of indandione such as the risk of bleeding. Danazol decreases effects of insulin and oral hypoglycemic drugs by affecting metabolism of carbohydrates, increasing blood sugar levels Danazol inhibits metabolism of carbamazepine and increase its blood levels increases blood concentrations of cyclosporine and tacrolimus hereby increasing risk of nephrotoxicity. Danazol also increases serum levels of glucagon.



Missed dose

Take the missed dose as soon as you remember. If it is almost time of your next dose just skip the missed dose and return to your schedule. Do not double dose this medication to make up the missed dose.



Overdose

This medication is not likely to produce life-threating symptoms. The most common effects of overdose are weight gain, menstrual problems, increased acne or facial hair growth, breast changes.



Storage

Store at room temperature between 20-25 C (68-77 F). Store away from moisture, heat, and sunlight. It is not recommended to store in a bathroom and places available for children.



Disclaimer

We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.
Antibiotics

Antibiotics is one of most prescribed group of medications. Antibiotics are antibacterial (antimicrobial agents) that kills bacteria(bactericidal) or stop the growth of the bacteria(bacteriostatic action).

Antibiotics are used to treat bacterial infections and are not indicated for the viral infections. Currently there is a big variety of antibiotics available. All the antibiotics are divided into two main groups according to the action mechanism:

  • Antibiotics with bactericidal action(penicillins, cephalosporins, aminoglycoside)
  • Antibacterial with bacteriostatic action(macrolides, tetracyclines)

Penicillins and cephalospororins are the most prescribed group of antibiotics. They belong to half-synthetic beta lactam antibiotics. These antibiotics work by inhibiting the enzymes responsible for the production of peptidoglycan. Peptidoglycan is a biopolimer that is a main structural component of the bacterial cell wall. The blockage of peptidoglycan synthesis leads to the lysis of the microorganisms.

Another group of preparations are aminoglycosides. However, these antibiotics are prescribed in rare cases. The most of aminoglycosides possesses nephrotoxicity, ototoxicity and cab cause neuromuscular blockage. Bactericidal action of aminoglycosides is related to the interfering with the synthesis of proteins on the ribisomes in the microbial cells. When aminoglycosides are used with penicillins and cephalosporins the sinergism against gram-positive and gram-negative microorganisms is observed.

Among all bacteriostatic antibiotics macrolides and tetracyclines are the most indicated groups. Therapeutic effect of macrolides is associated with inhibiting the synthesis of proteins on the ribosomes in the microbial cell. As usual macrolides exert bacteriostatic action, however in high amounts are able to exert bactericidal action on some microorganisms. Besides antibacterial action, some macrolides possesses immunomodulatory and anti-inflammatory action.

Another group of bacteriostatic antibiotics are used less frequently as many microorganisms became resistant to the this type of antibiotics. Bacteriostatic effect of the tetracyclines is associated with inhibiting the synthesis of proteins. Tetracycline are indicated in clamydia infections, rickettsial disease, some zoonosis, severe acne.

Antibiotics are indicated and used only in the cases of the bacteria is sensitive to the antibiotics. There some specific tests like antibiogram that will help to determine the right antibiotic and corresponding dose.