Generic Detrol (Tolterodine)
Detrol
Detrol is prescribed for treatment of spasms of the bladder muscles, overactive bladder characterized by symptoms of urinary urgency, frequency, and incontinence.
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1 mg x 30 pills
$76.99
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1 mg x 60 pills
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1 mg x 90 pills
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$2.08
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1 mg x 120 pills
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1 mg x 180 pills
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1 mg x 360 pills
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2 mg x 10 pills
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2 mg x 30 pills
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2 mg x 60 pills
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2 mg x 90 pills
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2 mg x 120 pills
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2 mg x 180 pills
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Product Description
Secondary efficacy measures included change in mean number of micturitions per day and mean volume voided per micturition at week 12 from baseline. No single QT correction method is known to be more valid than others. This is because the bladder muscle squeezes or contracts at a small volume and without the normal warning signals that capacity is being reached. If you have not discussed this with your doctor or are not sure why you are taking this medication, speak to your doctor. This means that less drug needs to be given daily due to efficient targeting of the bladder and so there are fewer side effects. By relaxing the muscles in the bladder, tolterodine improves your ability to control your urination. It is available by prescription only in a 2 and 4 mg extended release capsule formulation. Stop using this medicine and call your doctor right away if you have a rash; itching; hoarseness; lightheadedness, dizziness, or fainting; trouble breathing; trouble swallowing; or any swelling of your hands, face, mouth, or throat after using this medicine. This may contribute to greater patient satisfaction with treatment, resulting in patients staying on treatment longer. You are viewing prescription savings for zip code Tolterodine acts as a competitive antagonist of acetylcholine at postganglionic muscarinic receptors. Other medications can also increase the risk of QT prolongation when taken together with tolterodine. CYP2D6 extensive metabolizers had low serum concentrations of tolterodine and high concentrations of the active metabolite 5-HMT, while poor metabolizers had high concentrations of tolterodine and negligible active metabolite concentrations. Exposure levels of other metabolites of tolterodine e. Pharmacology, adverse reactions, warnings and side effects Detrol La 4mg Uses Tolterodine is used to treat overactive bladder with symptoms of urinary frequency, urgency, and incontinence. Reprint Permissions A single copy of these materials may be reprinted for noncommercial personal use only. Some side effects may occur that usually do not need medical attention. Myasthenia Gravis: If you have myasthenia gravis, tolterodine may make your symptoms worse. Unbound concentrations of tolterodine average 3. QT interval was measured over a hour period following dosing, including the time of peak plasma concentration T max of tolterodine and at steady state Day 4 of dosing. Tolterodine tartrate is a white, crystalline powder with a molecular weight of Is there a generic form of Detrol La? This leaflet does not take the place of talking with your doctor about your condition or your treatment. Detrol LA. Detrol LA is a type of medicine called an anticholinergic or antimuscarinic muscle relaxant. This study was not designed to make direct statistical comparisons between drugs or dose levels. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine. You are viewing prescription savings for zip code Categories : Muscarinic antagonists Pfizer brands Phenols Diisopropylamino compounds Benzhydryl compounds. Visit cvs. Pharmacology, adverse reactions, warnings and side effects Detrol La 4mg Uses Tolterodine is used to treat overactive bladder with symptoms of urinary frequency, urgency, and incontinence. Check with your doctor if you notice any symptom that worries you while you are taking this medication. It helps to reduce leaking of urine, feelings of needing to urinate right away, and frequent trips to the bathroom DETROL LA 4 mg was evaluated for the treatment of overactive bladder with symptoms of urge urinary incontinence and frequency in a randomized, placebo-controlled, multicenter, double-blind, Phase 3, week study. Effects on urodynamic parameters before and 1 and 5 hours after a single 6. They can be taken with or without food. If you have liver problems, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed. Muscarinic acetylcholine receptor modulators. Take Detrol exactly as prescribed by your doctor. QT interval was measured manually and by machine, and data from both are presented. A serious adverse event was reported by 1. The clearance of orally administered tolterodine immediate release was substantially lower in cirrhotic patients 1. Be sure to ask your doctor about anything you do not understand. The dose of this medicine will be different for different patients. Detrol LA tolterodine tartrate is indicated for the treatment of overactive bladder with symptoms of urge urinary incontinence, urgency and frequency. Carcinogenicity studies with tolterodine were conducted in mice and rats. You can also visit www. Detrol LA belongs to a group of drugs called antimuscarinic medications, which help the bladder muscles to relax. DETROL LA, like other antimuscarinic drugs, may decrease gastrointestinal motility and should be used with caution in patients with conditions associated with decreased gastrointestinal motility e. If you contact our Customer Support by one of the methods below, we will be able to assist you in locating the product you are looking for Detrol LA Descriptions Tolterodine is used to treat symptoms of an overactive bladder, such as incontinence loss of bladder control or a frequent need to urinate Uses Overactive Bladder. The remainder of the population is referred to as "extensive metabolizers. Side effects, drug interactions, warnings and precautions, and pregnancy safety should be reviewed prior to taking any medication Extended release: mg PO once daily; may lower dose to 1 mg twice daily based on response and tolerability. Forgot your password? The clearance of orally administered tolterodine immediate release was substantially lower in cirrhotic patients 1. This usually results in more frequent urination frequencyand sometimes, wetting accidents urge incontinence. For a complete list, ask your doctor or pharmacist. Important Note. Liver impairment can significantly alter the disposition Drtrol tolterodine immediate release. A side effect is an unwanted response to a medication when it is taken in normal doses. Both tolterodine and eDtrol exhibit a high specificity for muscarinic Dwtrol, since both show negligible activity or affinity for other neurotransmitter receptors and other potential cellular targets, such as calcium channels. Any specific brand name of this medication may not be available in all of the forms or approved for all of the conditions discussed here. Take the missed dose as soon as you remember. Effect of tolterodine on other drugs metabolized by Cytochrome P enzymes : Tolterodine immediate release does not cause clinically significant interactions with other drugs metabolized by the major drug-metabolizing CYP enzymes. Arsenic trioxide Trisenox ; 2. The active moiety, tolterodine, is a muscarinic receptor antagonist. Com for more details Detrol La 4mg Uses Tolterodine is used to treat overactive bladder with symptoms of urinary frequency, urgency, and incontinence. The 4 mg capsules are blue with symbol and 4 printed in white ink. Detrol LA reviews. Certainly chiropractic adjustment to the pelvis and low back can have an effect on the pudendal nerves that arise from the second, third and fourth sacral segments and control bladder function. This medicine may cause dryness in the mouth, nose, and throat. If you have not discussed this with your doctor or are not sure why you are taking this medication, speak to your doctor. Do not take extra medicine to make up the missed dose. The elimination half-life of tolterodine immediate release for both males and females is 2. Mean C max of tolterodine immediate release 1. Take the missed dose as soon as you remember. Follow the directions on your prescription label. I Accept. The remainder of the population is referred to as "extensive metabolizers. Many Detrol las can cause side effects. Explore Apps. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. However, the confidence intervals overlapped. Carcinogenicity studies with tolterodine were conducted in mice and rats. The chemical name of tolterodine tartrate is R -N,N-diisopropyl 2-hydroxymethylphenyl phenylpropanamine L-hydrogen tartrate. As well, some forms of this medication may not be used for all of the conditions discussed here. Skip the missed dose if it is almost time for your next scheduled dose. Do not stop taking this medication without consulting your doctor. Hide glossary Glossary Study record managers: refer to the Data Element Definitions if submitting registration or results information. Call your doctor for medical advice about side effects. Facts Detrop. However, no overall differences were observed in safety between older and younger patients on tolterodine in the Phase 3, week, controlled clinical studies; therefore, no tolterodine dosage adjustment for elderly patients is recommended. Avoid activities requiring mental alertness, such as driving, operating machinery, or performing hazardous work, if the medication affects you in this way. Invite Code. The child fully recovered. By relaxing the muscles in the bladder, tolterodine improves your ability to control your urination. Any specific brand name of this medication may not be available in all of the forms or approved for all of the conditions discussed here. Source: www. I accept the Terms and Privacy Policy. Glaucoma: People who have controlled narrow-angle glaucoma should discuss the benefits and risks of this medication with their doctor. Secondary efficacy measures included change in mean number of micturitions per day and mean volume voided per micturition at week 12 from baseline. At these exposure margins, no increase in tumors was found in either mice or rats.
Common use

Detrol La contains tolterodine tartrate, the substance of cholinergic (acetyl-choline) receptor blockers class. The medication is used to reduce spasms of the bladder muscles, overactive bladder with symptoms of urge urinary incontinence, and frequency.



Dosage and direction

Detrol La is taken two times a day. The recommended initial dose is 2mg taken twice daily. Treatment by long-acting Detrol La should be started by 4mg daily dose. If it is not well tolerated it should be reduced to 2mg. Dose adjustment is needed for the patients with impaired liver or kidney function. Do not open Detrol La capsules, do not crush or chew them. Swallow the tablet whole.



Precautions

Discuss with your doctor about following conditions you may have: glaucoma, kidney or liver disease, myasthenia gravis, or a personal or family history of "Long QT syndrome." This medicine may change your thinking reactions or ability to concentrate. Be careful while driving or operating machinery.



Contraindications

Detrol La cannot be used to treat patients with uncontrolled narrow-angle glaucoma, obstruction to the flow of urine (urinary retention), poor emptying of the stomach (gastric retention), allergic reaction to the components of the drug in history.



Possible side effect

Besides allergic reactions (hives, facial swelling, rash, skin eruptions, difficulty breathing) Detrol La may cause chest pain, fast or uneven heart rate, confusion, painful or difficult urination, hallucinations, urinating less than usual or not at all.



Drug interaction

Inform your doctor about all prescribed and over-the-counter medications you are using and especially about the drugs which may interfere with elimination of tolterodine by the liver which include: cyclosporine (Gengraf, Neoral, Sandimmune), clarithromycin (Biaxin), azithromycin (Zithromax), erythromycin, telithromycin (Ketek), pentamidine (NebuPent, Pentam), sparfloxacin (Zagam), itraconazole (Sporanox), ketoconazole (Nizoral), and miconazole (Monistat, Micatin), arsenic trioxide (Trisenox), chloroquine (Arelan) or halofantrine (Halfan), levomethadyl (Orlaam), or methadone (Dolophine, Methadose), vinblastine (Velban), medications used to treat psychiatric disorders such aschlorpromazine (Thorazine), mesoridazine (Serentil), pimozide (Orap), haloperidol (Haldol), or thioridazine (Mellaril), heart rhythm medicine such as disopyramide (Norpace), procainamide (Procan, Pronestyl), amiodarone (Cordarone, Pacerone), dofetilide (Tikosyn), sotalol (Betapace), quinidine (Cardioquin, Quinaglute).



Missed dose

Never take a double dose of this medication. If it is almost time of the next dose just skip the missed portion and continue to take the medicine according to the schedule.



Overdose

Symptoms of overdose include blurred vision, dry mouth, and fast heartbeat.



Storage

Store at room temperature 15-30 C (59-86 F) away from moisture and heat.



Disclaimer

We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.
Antibiotics

Antibiotics is one of most prescribed group of medications. Antibiotics are antibacterial (antimicrobial agents) that kills bacteria(bactericidal) or stop the growth of the bacteria(bacteriostatic action).

Antibiotics are used to treat bacterial infections and are not indicated for the viral infections. Currently there is a big variety of antibiotics available. All the antibiotics are divided into two main groups according to the action mechanism:

  • Antibiotics with bactericidal action(penicillins, cephalosporins, aminoglycoside)
  • Antibacterial with bacteriostatic action(macrolides, tetracyclines)

Penicillins and cephalospororins are the most prescribed group of antibiotics. They belong to half-synthetic beta lactam antibiotics. These antibiotics work by inhibiting the enzymes responsible for the production of peptidoglycan. Peptidoglycan is a biopolimer that is a main structural component of the bacterial cell wall. The blockage of peptidoglycan synthesis leads to the lysis of the microorganisms.

Another group of preparations are aminoglycosides. However, these antibiotics are prescribed in rare cases. The most of aminoglycosides possesses nephrotoxicity, ototoxicity and cab cause neuromuscular blockage. Bactericidal action of aminoglycosides is related to the interfering with the synthesis of proteins on the ribisomes in the microbial cells. When aminoglycosides are used with penicillins and cephalosporins the sinergism against gram-positive and gram-negative microorganisms is observed.

Among all bacteriostatic antibiotics macrolides and tetracyclines are the most indicated groups. Therapeutic effect of macrolides is associated with inhibiting the synthesis of proteins on the ribosomes in the microbial cell. As usual macrolides exert bacteriostatic action, however in high amounts are able to exert bactericidal action on some microorganisms. Besides antibacterial action, some macrolides possesses immunomodulatory and anti-inflammatory action.

Another group of bacteriostatic antibiotics are used less frequently as many microorganisms became resistant to the this type of antibiotics. Bacteriostatic effect of the tetracyclines is associated with inhibiting the synthesis of proteins. Tetracycline are indicated in clamydia infections, rickettsial disease, some zoonosis, severe acne.

Antibiotics are indicated and used only in the cases of the bacteria is sensitive to the antibiotics. There some specific tests like antibiogram that will help to determine the right antibiotic and corresponding dose.