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Product Description
Some drugs can interact with indinavir, increasing or decreasing its levels in your body. Results may be different when indinavir is taken in combination with other PIs, such as ritonavir. Drugs to watch out for include other ARVs, drugs to treat tuberculosis see Indinavir sheetfor erectile dysfunction such as Viagrafor heart rhythm antiarrhythmicsand for migraine headaches. What tips would you provide a friend before taking Indinavir? Indinavir and other protease inhibitors Some specialists prescribe indinavir in combination of with another protease inhibitor called ritonavir Norvir. Midazolam, triazolam: Competition for CYP3A4 by indinavir could result in inhibition of the metabolism of these drugs and create the potential for serious or life-threatening events, such as arrhythmias or prolonged sedation. Tat antagonists. It can also cause unconjugated indirect hyperbilirubinemia. Or, he may take it with other liquids such as skim milk, juice, coffee, or tea or with a light meal. Indinavir as the sole protease inhibitor in a regimen The recommended dose of indinavir, when used as the sole protease inhibitor in a regimen, is mg every eight hours. These catalytic Asp residues carry out the hydrolytic cleavage of the polyprotein. HIV protease acts like a chemical scissors. Unlike the case when indinavir is the only protease inhibitor, indinavir in combination with ritonavir can be taken with or without meals. J Infect Dis ; Take indinavir on an empty stomach, 1 hour before meals or 2 hours after meals, with water, skim or nonfat milk, juice, coffee, or tea. Indinavir is an inhibitor of cytochrome P 3A4 CYP3A4and may alter serum concentrations of other drugs metabolized by this pathway, including certain benzodiazepines, cholesterol-lowering agents, ergot derivatives, rifampin, phosphodiesterase type 5 PDE5 inhibitors sildenafil, tadalafil, or vardenafiland others. Taking St. Talk to your doctor about eating grapefruit and drinking grapefruit juice while taking this medication. Take indinavir on an empty stomach, 1 hour before meals or 2 hours after meals, with water, skim or nonfat milk, juice, coffee, or tea. Resistance and cross-resistance Over time, as new copies of HIV are made in the body, the virus changes its structure. You can print this fact sheet on a single page in Microsoft Word. Indinavir, sold under the brand name Crixivan, is a type of anti-HIV drug antiretroviral called a protease inhibitor PI. Administer this drug and indinavir at least 1 hour apart on an empty stomach. When indinavir is used as the only protease inhibitor in a regimen, for best absorption, this drug should be taken with water on an empty stomach, that is, either one hour before or two hours after a meal. So far, however, the many benefits of ART are much greater than the increased risk of cardiovascular disease or other side effects. There are restrictions on what sorts of food may be eaten concurrently with the unboosted indinavir treatment. Available forms Available by prescription only Capsules: mg, mg, mg, and mg. Unable to actively cleave the nascent proteins into their appropriate form, HIV is unable to mature and proliferate, allowing the patients immune system to fight off the infection more easily. Make sure that your health care provider knows about ALL drugs and supplements you are taking. Effect of high-dose vitamin C on the steady-state pharmacokinetics Infinavir the protease inhibitor indinavir in healthy volunteers. Indinavir is rarely used in Indunavir clinical practice. Adverse Effects Indinavir crystalizes in the urinary tract and causes kidney stones; thus individuals taking indinavir are advised to drink at least 1. Other Requirements Back to Top. Did you experience many side effects while taking this drug? Dosage and formulations Because of the complex regimens and side effects associated with the use of indinavir, this drug is rarely used in Canada and other high-income countries. Tell your doctor immediately if you have any of the following symptoms while you are taking indinavir: extreme thirst, frequent urination, extreme hunger, blurred vision, or weakness. Later on, Merck faced serious backlash from community members who though did not like the pricing and distribution of the drug. Journal of Molecular Biology. Opioid Replacement Therapy. It is also called Crixivan. Does it still have a role? Indinavir can also cause kidney stones, but drinking a minimum of 1. How likely would you be to recommend Indinavir to a friend? Indinavir Precautions Back to Top. Back Submit. Prolonged bouts of higher-than-normal blood sugar levels may lead to diabetes, although for the average person, the risk of developing this complication is low. If you have trouble digesting dairy products, you may have more stomach problems with Indinavir. Amprenavir, saquinavir: Increases plasma levels of these drugs. Swollen kidneys due to blocked urine flow occurred rarely.
Common use

Indinavir is used to treat HIV infection in some patients when used in combination with certain other medicines. It is an HIV protease inhibitor. It works by slowing the growth of HIV, the virus that causes AIDS.



Dosage and directions

Take Indinavir by mouth on an empty stomach at least 1 hour before or 2 hours after eating. You may also take it with a light meal that is low in calories, fat, and protein. Take Indinavir with water. You may also take it with other liquids such as skim milk, juice, coffee, or tea. It is recommended to drink extra fluids.



Precautions

Before using Indinavir discuss with your doctor if you are pregnant, planning become pregnant or breast-feeding, if you have allergy to food, medicines, or other substances, if you are taking any prescribed or not prescribed medications, herbal products, or dietary supplements, have cirrhosis, liver or kidney problems, diabetes, high blood sugar, high cholesterol, kidney stones, urinary problems (white blood cells in the urine), or blood problems (hemophilia hemolytic anemia).



Contraindications

Do not use Indinavir if you are allergic to its components; you are taking alfuzosin, amiodarone, astemizole, atazanavir, certain benzodiazepines (eg, alprazolam, oral midazolam, triazolam), cisapride, conivaptan, an ergot alkaloid (eg, ergonovine, ergotamine), erythromycin, certain HMG-CoA reductase inhibitors (lovastatin, rosuvastatin, simvastatin), pimozide, a proton pump inhibitor (omeprazole), ranolazine, rifampin, salmeterol, a serotonin 5-HT1 receptor antagonist (eg, eletriptan, sumatriptan), St. John's wort, or terfenadine, sildenafil for pulmonary arterial hypertension (PAH).



Possible side effect

The common side effects are bad taste in the mouth; diarrhea; dizziness; drowsiness; headache; nausea; tiredness; vomiting; weakness. Seek urgent medical attention if you experience the following severe side effects: allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); back, flank, or side pain; bloody or cloudy urine; change in the amount of urine; changes in appetite; chest pain; chills; confusion; dark urine; fast or irregular heartbeat; fever; flushed face; heartburn; ingrown toenails; joint or muscle aches; mental or mood changes; numbness of the mouth; one-sided numbness or weakness; pain while urinating; pale stools; red, swollen, or blistered skin; severe dizziness or fainting; severe or persistent stomach pain or upset; speech problems; swelling of the feet, hands, lower legs, or stomach; unusual hair loss; unusual paleness; unusual tiredness; unusually dry skin; vision changes; weight changes; yellowing of the skin or eyes.



Drug interaction

Tell your doctor if you are taking any drugs especially about the following: amiodarone, astemizole, certain benzodiazepines (alprazolam, midazolam,triazolam), cisapride, ergot alkaloids (ergotamine), erythromycin, pimozide, salmeterol, or terfenadine; alfuzosin, conivaptan, certain HMG-CoA reductase inhibitors (atorvastatin, lovastatin, rosuvastatin, simvastatin), ranolazine, serotonin 5-HT1 receptor antagonists (eletriptan, sumatriptan), or sildenafil (for PAH); atazanavir; proton pump inhibitors (eg, omeprazole), rifampin, or St. John's wort.



Missed dose

If you miss a dose of Indinavir by more than 2 hours, do not take that dose. Take your next dose as scheduled. If you miss the dose by less than 2 hours, take that dose immediately and then return to your regular dosing schedule. It is important not to miss doses of Indinavir. Do not take 2 doses at once.



Overdose

If you thin that overdosed Indinavir seek urgent medical help. Overdose symptoms are blood in the urine; diarrhea; lower back pain; nausea; vomiting.



Storage

Store Indinavir at room temperature, between 59 and 86 degrees F (15 and 30 degrees C), in the original bottle. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Indinavir out of the reach of children and away from pets.



Disclaimer

We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.
Antibiotics

Antibiotics is one of most prescribed group of medications. Antibiotics are antibacterial (antimicrobial agents) that kills bacteria(bactericidal) or stop the growth of the bacteria(bacteriostatic action).

Antibiotics are used to treat bacterial infections and are not indicated for the viral infections. Currently there is a big variety of antibiotics available. All the antibiotics are divided into two main groups according to the action mechanism:

  • Antibiotics with bactericidal action(penicillins, cephalosporins, aminoglycoside)
  • Antibacterial with bacteriostatic action(macrolides, tetracyclines)

Penicillins and cephalospororins are the most prescribed group of antibiotics. They belong to half-synthetic beta lactam antibiotics. These antibiotics work by inhibiting the enzymes responsible for the production of peptidoglycan. Peptidoglycan is a biopolimer that is a main structural component of the bacterial cell wall. The blockage of peptidoglycan synthesis leads to the lysis of the microorganisms.

Another group of preparations are aminoglycosides. However, these antibiotics are prescribed in rare cases. The most of aminoglycosides possesses nephrotoxicity, ototoxicity and cab cause neuromuscular blockage. Bactericidal action of aminoglycosides is related to the interfering with the synthesis of proteins on the ribisomes in the microbial cells. When aminoglycosides are used with penicillins and cephalosporins the sinergism against gram-positive and gram-negative microorganisms is observed.

Among all bacteriostatic antibiotics macrolides and tetracyclines are the most indicated groups. Therapeutic effect of macrolides is associated with inhibiting the synthesis of proteins on the ribosomes in the microbial cell. As usual macrolides exert bacteriostatic action, however in high amounts are able to exert bactericidal action on some microorganisms. Besides antibacterial action, some macrolides possesses immunomodulatory and anti-inflammatory action.

Another group of bacteriostatic antibiotics are used less frequently as many microorganisms became resistant to the this type of antibiotics. Bacteriostatic effect of the tetracyclines is associated with inhibiting the synthesis of proteins. Tetracycline are indicated in clamydia infections, rickettsial disease, some zoonosis, severe acne.

Antibiotics are indicated and used only in the cases of the bacteria is sensitive to the antibiotics. There some specific tests like antibiogram that will help to determine the right antibiotic and corresponding dose.