Generic Macrobid (nitrofurantoin monohydrate)
Macrobid is used to treat infections specific to urinary tract (acute cystitis).
Per Pills
50 mg x 120 pills
50 mg x 180 pills
50 mg x 360 pills
Per Pills
100 mg x 30 pills
100 mg x 60 pills
100 mg x 90 pills
100 mg x 120 pills
100 mg x 180 pills
100 mg x 360 pills
Product Description
Spontaneous reports suggest a higher proportion of pulmonary reactions, including fatalities, in elderly patients; these differences appear Macrobid be related to the higher proportion of elderly patients receiving long-term nitrofurantoin therapy. The following two tabs change content below. Macronid FDA categorizes medications based on safety for use during pregnancy. Peripheral neuropathy, which may become severe or irreversible, has occurred. Nitrofurantoin warnings. Re-challenge with the drug at a later date is not recommended, as the reaction may have a hypersensitivity component and recur when the drug is resumed. Email this page. The contents herein are for informational purposes only. Nitrofurantoin belongs to the class of medications called antibiotics. Urinary tract infections UTIs are very common in children. Time limit is exhausted. Acute reactions have been estimated to occur in about one in women who take the drug. The following two tabs change content below. Close monitoring of the pulmonary condition of patients receiving long-term therapy is warranted. Stop taking the medication and seek immediate medical attention Macrboid any of the following occur:. Nitrofurantoin exerts greater effects on bacterial cells than mammalian cells because bacterial cells activate the drug more rapidly. Geriatric Patients: Spontaneous reports suggest a higher proportion of pulmonary reactions in the elderly, including fatalities; these differences appear to be related to the higher proportion of elderly patients receiving long-term nitrofurantoin therapy. Macrobid Images. Patients should be advised to take Macrobid with food ideally breakfast and dinner to further enhance tolerance and improve drug absorption. Get emergency medical help if you have signs of an allergic reaction hives, difficult Macrboid, swelling in your face or throat or a severe skin reaction fever, sore throat, burning eyes, skin pain, red or purple skin rash Macrobiv blistering and peeling. The chemical name of nitrofurantoin macrocrystals is 1-[[[5-nitrofuranyl]methylene]amino]-2,4-imidazolidinedione. Drug Status Availability Prescription only Rx. Macrobid is an antibiotic. Acute pulmonary reactions are commonly manifested by fever, chills, cough, chest pain, dyspnea, pulmonary infiltration with consolidation or pleural effusion on x-ray, and eosinophilia. Drug Class. Provision of cephalexin and adjustment based on culture results is a perfectly reasonable approach, though idiosyncrasies of ED practice may make this unrealistic patients with poor follow-up, delayed culture callback system, etc. Can lifestyle changes help urinary tract infections? Keep this and all medicines out of the reach of children. Uses of Macrobid Back to Top. Many or all strains of the following genera are resistant to nitrofurantoin: [15]. Check with your doctor if you notice any symptom that worries you while you are taking this medication. Do not take a double dose to make up for a missed one. As a result of such inactivations, the vital biochemical processes of protein synthesis, aerobic energy metabolism, DNA synthesis, RNA synthesis, and cell wall synthesis are inhibited. Nitrofurantoin belongs to a class of drugs called antimicrobials or antibiotics. It may also help if you avoid rich or spicy food. Every effort has been made to ensure that the information provided by Cerner Multum, Inc. The broad mechanism of action for this drug likely is responsible for the low development of resistance to its effects, as the drug affects many different processes important to the bacterial cell. Children: The safety and effectiveness of using this medication have not been established for children less than one month of age. Drug information contained herein may be time sensitive. This is not a complete list of Macrobid drug interactions. Medications can interact with certain foods. Some people may experience side effects other than those listed. Follow the directions on your prescription label carefully. Do not take nitrofurantoin while breastfeeding if your baby has a rare condition called glucosephosphate dehydrogenase G6PD deficiency. Please enter text to search. To reduce the development of drug-resistant bacteria and maintain the effectiveness of Macrobid and other antibacterial drugs, Macrobid should Macrobid used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. Macrobid is available as capsules and can be given two times a day. To make sure it's safe for you, tell your doctor if you have :. Nitrofurantoins lack the broader tissue distribution of other therapeutic agents approved for urinary tract infections. Finish taking all of your medication. We'll break down a kidney infection vs. Hepatic reactions, including hepatitis, cholestatic jaundice, chronic active hepatitis, and hepatic necrosis, occur rarely. Read more about what to do if you're on the pill and you're being sick or have diarrhoea. There may be an interaction between nitrofurantoin and any of the following: antacids containing magnesium trisilicate bacillus Calmette-Guerin BCG dapsone eplerenone prilocaine probenecid norfloxacin spironolactone sulfinpyrazone typhoid vaccine If you are taking any of these medications, speak with your doctor or pharmacist. This can help your doctor prevent possible interactions. If it is almost time for the next dose, skip the missed dose and take your next dose at the regular time. Clostridium difficile- associated Macrobjd CDAD - may range in severity from mild diarrhea to fatal colitis. Macrobie Close. The medicine will come with a syringe or spoon to help you take the right amount. Study 3: Nordeng, Lupattelli, Romoren, and Koren. Monitor patients periodically for changes in biochemical Macrobid that would indicate liver injury. It is not known whether this is of clinical significance, but the combination should be avoided. That means two things:. The Annals of Pharmacotherapy. Never take 2 doses at the same time. Cefotaxime is administered either intravenously or intramuscularly and therefore has questionable relevance to this study. In an interview with the Financial Times, Nirmal Mulye, Nostrum chief executive, said that there was a "moral requirement to sell the product at the highest price. Hemolytic anemia - hemolysis appears to be linked to a glucosephosphate dehydrogenase deficiency in the red blood cells of the affected patients. This study is important because UTI is routinely treated empirically. Macrobid belongs to a group of drugs called nitrofuran antibiotics. Nitrofurantoin has been detected in human Macrobid milk in trace amounts. Black Box Warnings. Talk to your doctor about whether you should continue breast-feeding. The administration of high doses of nitrofurantoin to rats causes temporary spermatogenic arrest; this is reversible on discontinuing the drug. What will it do for me? Symptoms such as pelvic pain and the frequent urge to urinate can keep you up all…. Two chronic rodent bioassays utilizing male and female Sprague-Dawley rats and two chronic bioassays in Swiss mice and in BDF 1 mice revealed no evidence of carcinogenicity. Nitrofurantoin For more information on this medication choose from the list of selections below. Archived from the original on 8 September In the U.
Common use

Macrobid is a wide spectrum antibiotic. It inhibits construction of a bacterial cell wall, synthesis of a bacterial DNA and RNA, proteins, inhibits aerobic metabolism. This medication is used to treat bacterial infections of the urinary tract caused by E. Coli, Enterobacter cystitis, Staphylococcus aureus, and Enterococcus, Klebsiella such as pyelitis, pyelonephritis, cystitis, urethritis, to prevent infections during urological surgeries, cystoscopy, catheterization. Macrobid is a sustained release macrocrystalline form of the antibiotic. Nitrofuranton is also available in a microcrystalline form (Furadantin), and a macrocrystalline form (Macrodantin). Absorption of the medication depends on the size of crystals and presence of food in the gastrointestinal tract.

Dosage and directions

Take 100 mg of Macrobid every 12 hours. Taking with a meal or milk increase its absorption and helps to avoid your stomach upset. Usual course of treatment continues seven days. Follow all recommendations of your doctor. Do not stop or start this medication without your doctor's permission.


Before to take Macrobid inform your doctor if you have kidney disease, anemia, diabetes, an electrolyte imbalance, glucose-6-phosphate dehydrogenase (G6PD) deficiency, vitamin B deficiency, any type of debilitating disease. This medication can change results of urine glucose tests. This medication may cause diarrhea, if you have watery or bloody stools inform your doctor about. Do not take any antidiarrhea medication unless it was administered to you as diarrhea may be a sign of a new infection.


Macrobid cannot be used in patients with kidney or liver failure, jaundice in history, glucose-6-phosphate dehydrogenase deficiency, acute porphyria, pregnancy, in children under 12 years of age. Breastfeeding should be interrupted when on Macrobid.

Possible side effect

The most common adverse reactions are headache, dizziness, drowsiness, allergic reactions (rash, itching), nausea, vomiting. In rare cases diarrhea, loss of appetite, pseudomembranous colitis, and abdominal pain may occur.

Drug interaction

High doses of probenecid (Benemid) or sulfinpyrazone (Anturane) can inhibit secretion by kidney channels and decrease urine levels of Macrobid. Consequently blood concentrations of Macrobid increases as well as the risk of toxicity. Antibacteral effect of Macrobid is reduced by nalidixic acid, while is absorption is decreased by antacids which contain magnesium trisilicate. Co-administration with quinolone antibiotics such as norfloxacin (Noroxin) reduces their effects.

Missed dose

If you miss a dose, take it as soon as you remember unless it is almost time of your next dose. If it is near the time of the next dose, skip the missed dose and return dosing schedule. Do not double the dose to make up the missed dose.


Symptoms of overdose include nausea or vomiting. If you suppose that too much of Macrobid was taken seek immediate medical attention.


Store at room temperature in a tight container, away from moisture and humidity.


We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.

Antibiotics is one of most prescribed group of medications. Antibiotics are antibacterial (antimicrobial agents) that kills bacteria(bactericidal) or stop the growth of the bacteria(bacteriostatic action).

Antibiotics are used to treat bacterial infections and are not indicated for the viral infections. Currently there is a big variety of antibiotics available. All the antibiotics are divided into two main groups according to the action mechanism:

  • Antibiotics with bactericidal action(penicillins, cephalosporins, aminoglycoside)
  • Antibacterial with bacteriostatic action(macrolides, tetracyclines)

Penicillins and cephalospororins are the most prescribed group of antibiotics. They belong to half-synthetic beta lactam antibiotics. These antibiotics work by inhibiting the enzymes responsible for the production of peptidoglycan. Peptidoglycan is a biopolimer that is a main structural component of the bacterial cell wall. The blockage of peptidoglycan synthesis leads to the lysis of the microorganisms.

Another group of preparations are aminoglycosides. However, these antibiotics are prescribed in rare cases. The most of aminoglycosides possesses nephrotoxicity, ototoxicity and cab cause neuromuscular blockage. Bactericidal action of aminoglycosides is related to the interfering with the synthesis of proteins on the ribisomes in the microbial cells. When aminoglycosides are used with penicillins and cephalosporins the sinergism against gram-positive and gram-negative microorganisms is observed.

Among all bacteriostatic antibiotics macrolides and tetracyclines are the most indicated groups. Therapeutic effect of macrolides is associated with inhibiting the synthesis of proteins on the ribosomes in the microbial cell. As usual macrolides exert bacteriostatic action, however in high amounts are able to exert bactericidal action on some microorganisms. Besides antibacterial action, some macrolides possesses immunomodulatory and anti-inflammatory action.

Another group of bacteriostatic antibiotics are used less frequently as many microorganisms became resistant to the this type of antibiotics. Bacteriostatic effect of the tetracyclines is associated with inhibiting the synthesis of proteins. Tetracycline are indicated in clamydia infections, rickettsial disease, some zoonosis, severe acne.

Antibiotics are indicated and used only in the cases of the bacteria is sensitive to the antibiotics. There some specific tests like antibiogram that will help to determine the right antibiotic and corresponding dose.