Generic Methotrexate
Methotrexate
Methotrexate is an antimetabolite used to treat certain types of cancer.
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Product Description
Sodium aurothiomalate Sodium aurothiosulfate Auranofin Aurothioglucose Aurotioprol. Methotrexate can be taken with other medications. What to do if you miss a dose: Take your dose Methotrexahe soon Methotrxeate you remember. Methotrexate can be given to people with various types of arthritis and Methitrexate conditions, including:. Symptoms include trouble passing urine, muscle weakness or cramps, upset stomach or no appetite, vomiting, loose stools, or feeling sluggish. How to Fall Asleep in 10, 60, or Seconds. Methotrexate may cause liver damage, especially when it is taken for a long period of time. Share on Facebook Tweet LinkedIn. Call your doctor right away if you have serious side effects. If your symptoms are severe, call or go to the nearest emergency room right away. Methotrexate is one of the most effective and commonly used medications in the treatment of rheumatoid arthritis and other forms of inflammatory arthritis, and also may be used to treat lupusinflammatory myositis, vasculitisand some forms of childhood arthritis. When methotrexate is less effective: When methotrexate is used with certain drugs, it may not work as well to treat your condition. Symptoms are; difficulty with speech, paralysis of the arms and legs, seizures, or coma. These response rates were sustained for a 2-year period medianand many patients could either reduce or completely discontinue the concomitant corticosteroid medication. This can be harmful or prevent the drug from working well. Methotrexate is still used intravenously in high doses to treat cancer. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use methotrexate only for the indication prescribed. Methotrexate Images. For both men and women: Do not conceive a child get pregnant while taking methotrexate. People prescribed methotrexate Methotrexate be closely monitored by their doctor for these effects. The combination of MTX with biologics is always superior to either monotherapy. Methotrexate self-injectable solution is used to treat psoriasis. It is also used to treat severe psoriasis and and certain forms of rheumatoid arthritis. Ask your doctor or pharmacist for a list of the ingredients. MTX as monotherapy or in a combination with other drugs, including glucocorticoids and biologics, is the most common treatment for RA patients in the world today, and MTX is considered the anchor drug for the vast majority of therapeutic strategies [ Pincus et al. It is also important information to carry with you in case of emergencies. While clinical parameters morning stiffness, pain and ESR improved significantly, no significant differences in the development of erosions before and after that treatment were observed. All rights reserved. This interferes with the growth of cancer cells, which are eventually destroyed by the body. The "normal" cells will grow back and be healthy but in the meantime, side effects occur. How to tell if the drug is working: You may have signs of improvement. Caregivers should wear rubber gloves while cleaning up a patient's body fluids, handling contaminated trash or laundry or changing diapers. Related Drugs. Methotrsxate an injection into the muscle intramuscular, IM. Tell your doctor if you have or have ever had a low number of any type of blood cells Methktrexate any Merhotrexate problem with your blood cells. If you are female, you should continue to Methotrexaet birth control until Methofrexate have had one menstrual period that began after you stopped taking methotrexate. Methotrexate can cause mouth ulcers in a few patients, in the beginning of treatment. If you have severe side effects, you should contact a health professional for advice. Rheumatology Oxford 49 : —45 Epub 16 August In case of overdose, call the poison control helpline at When nothing else helps, switching from oral methotrexate to the injectable version can eliminate GI distress. Methotrexate is usually not taken every day. How it makes you feel The correct dose of methotrexate commonly between 7. Tell your doctor if you have or have ever had excess fluid in your stomach area or in the space around your lungs and if you have or have ever had kidney disease. Interactions Low-dose methotrexate interacts with drugs that inhibit the way the body uses folic acid, such as the antibiotics trimethoprim with sulfamethoxazole Bactrim, Resprim and trimethoprim alone Triprim, Alprim. Taken together, these interesting results should lead to further studies on the subject. Disclaimer: Our goal is to provide you with the most relevant and current information. Transactions of Metbotrexate American Clinical and Climatological Association. These conditions and medications may increase the risk that you will develop serious side Methptrexate of methotrexate. Your doctor may need to change the doses of your medications or monitor you Methotrexxte for side effects. As a result, more of a drug may stay in your body for a longer time. It is not to be confused with Aminopterin. Increased side effects from methotrexate: Taking Methotrextae with certain medications raises your Methotrexxte of Methogrexate effects from methotrexate. Arthritis Rheum. Methotrexate Rheumatrex, Trexall, Otrexup, Rasuvo Methotrexate is one of the most effective and commonly used medications Methotrexzte the treatment of rheumatoid arthritis and other forms of inflammatory arthritis, and also may be used to treat lupusinflammatory myositis, vasculitisand some forms of childhood arthritis. There are only a limited number of trials that fulfil essential methodological requirements. As usual, stable doses of nonsteroidal anti-inflammatory drugs NSAIDs and prednisone could be administered in addition. If you are a manuse a condom to keep from causing a pregnancy while you are using methotrexate. The potential of folic acid interfering with MTX absorption can be overcome by giving it 24 hours prior to the weekly MTX dose or 24 hours following the dose [ Morgan et al. You should discuss this with your doctor. The most common adverse effects include: hepatotoxicity liver damageulcerative stomatitisleukopenia and thus predisposition to infection, nausea, abdominal pain, fatigue, fever, dizziness, acute pneumonitisrarely pulmonary fibrosisand kidney failure. Use of this Site All information contained within the Johns Hopkins Arthritis Center website is intended for educational purposes only. Warning about treatments that increase side effects: Some medications and treatments can increase the side effects of methotrexate. Your doctor should monitor you for these and other side effects. Skin reactions warning: Methotrexate can cause skin reactions that could be fatal cause death. Blood work will be done every weeks to check your liver function. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. If you have questions about your methotrexate treatment, speak with your doctor or pharmacist. Methotrexate can harm your liver, especially if you also use certain other medicines for Methotreexate, tuberculosisdepressionbirth control, hormone replacement, high cholesterolheart problems, high blood pressureseizuresor pain or arthritis medicines including acetaminophenTylenolAdvilMotrinand Aleve. An overdose can cause problems that include:. Liver problems warning: Methotrexate can cause end-stage liver disease fibrosis and cirrhosis. These medications raise your risk of problems with your stomach, bowel, or bone marrow. You should not need a new prescription for this medication to be refilled. MTX was the most commonly administered drug in patients with RA Use of this Site All information contained within the Johns Hopkins Arthritis Center website is intended for educational purposes only. What special dietary instructions should I follow? Methotrexate given concomitantly Methotrrexate radiotherapy may increase the risk of soft tissue necrosis and osteonecrosis. Previously Methltrexate was recommended that men stop methotrexate three months before trying for a baby, but research has now been done that suggests that they may not need to. Methotrexate belongs to a class Mwthotrexate drugs called antimetabolites, or folic Methotrexqte antagonists. Methotrexate can pass into body fluids urine, feces, vomit. Improvements in Methotrexate and other conditions usually are first seen in three - six weeks. Symptoms are; difficulty with speech, paralysis of the arms and legs, seizures, or coma. You must use an effective form of birth control while taking methotrexate and for at least 3 months after the methotrexate is stopped. If these effects are mild, they may go away within a few days or a couple of weeks. If you will be self-injecting methotrexate, your healthcare provider will show you or your caregiver how to do it. Call your doctor right away if you have serious side effects. Caregivers should wear rubber gloves while cleaning up a patient's body fluids, handling contaminated trash or laundry or changing diapers. I want information on ways to remember the AF in my will, trust or other financial planning vehicles. Other names. Inflammation can cause swelling, heat, redness and pain. Overall, the question of Methtrexate or to what degree folate supplementation may affect Methhotrexate efficacy has still not been completely answered. Give today. However, there are some methodological problems with comparisons, one of Methotrexate is that in most of the early trials rather low dosages of MTX Methootrexate used. For pregnant women: Methotrexate can cause serious harm to a pregnancy. Call your doctor right away if you have trouble breathing, shortness of breath, chest pain, or a dry cough while taking this drug. Do not receive any kind of immunization or vaccination without your doctor's approval while taking methotrexate. Available for Android and iOS devices. You should speak to your doctor about this first. Chan notes that adenosine also causes fibrosis, or buildup of scar tissue, in the liver. Sudden weight gain. An observational study. In other words, high doses may produce more severe side effects.

Methotrexate - opinion you

Tastefully, it is able to use birth Methotexate to jaundice matrix because methotrexate may harm the baby if a veterinarian does occur. Take half the pills in the degradation and the other half 12 hours later, moderately with food. Methotrexate trine as meth'' oh trex' ate. It has also been culminated the anchor drug [ Pincus et al. Email Salt. Individuals should Methottexate a qualified health care provider for professional medical advice, diagnosis and treatment of a medical or health condition. You must use the correct dose. Meaning, your ability to conceive or father a child may be affected by methotrexate. Several smaller open and retrospective studies with MTX suggest a positive effect of the drug and seem to slow down the destructive course of the disease [ Kremer and Lee, ]. There are several different types of psoriasis. If these effects occur, your doctor may interrupt your treatment with this drug.
Common use

Methotrexate is an antimetabolite used to treat certain types of cancer. It inhibits dihydrofolate reductase, an important enzyme responsible for the synthesis of nucleotides for DNA. This medication inhibits synthesis of DNA, DNA reparation and cell mitosis. Cells of malignant tumor, bone marrow, embryonic cells, epithelial cells of the intestinal mucosa, bladder, oral cavity are the most sensitive to it.

Methotrexate is used in treatment of breast cancer, squamous cell carcinoma of the head and neck, lung cancer, trophoblastic tumor, cervical cancer, ovarian cancer, bladder cancer, colorectal cancer, esophagus cancer, stomach cancer, pancreatic cancer, testicular cancer, acute lymphoblastic leukemia and many others.



Dosage and direction

Take exactly as prescribed by your physician. Take Methotrexate orally with or without food. Do not chew or crush the tablet. To treat rheumatoid arthritis and psoriasis Methotrexate is taken weekly. Starting dose 7.5 mg of the medication once a week or 2.5 mg each twelve hours three times also once weekly. Treatment of cancer requires individual dosage and treatment only under control of your doctor.



Precautions

Caution should be exercised in the patients with ascites, dehydration, obstructive diseases of the digestive tract, pleural or peritoneal effusion, chronic renal failure, parasitic and infectious diseases of viral, fungal or bacterial origin due to the possible high risk of severe generalized disease development. Methotrexate toxicity increases in the individuals with herpes simplex, herpes zoster, chickenpox, measles, amoebiasis, strongyloidiasis (helminthosis caused by threadworm with allergic symptoms at the beginning of the disease), gout (also in history), infection and inflammation of mucosa in the mouth, nausea and vomiting (due to dehydration), stomach and duodenal ulcerations, ulcerative colitis, prior chemotherapy or radiotherapy, asthenia. When Metheotrexate is used to treat cancer cautiousness is need in the patients with aciduria (urine pH less than 7) and inhibited bone marrow hematopoiesis. Do not expose yourself to sun rays. Immunization by vaccines should be avoided for 3-12 months since the course of treatment with Methotrexate was finished. Men and women should use safe contraception as this drug is very toxic for an unborn baby.



Contraindications

This medicine cannot be administered to the patients with hypersensitivity to its components, immune deficiency, pregnant and breastfeeding women. When Methotrexate is used to treat patents with psoriasis or rheumatic diseases it cannot be used if they also have heavy suppression of bone marrow hematopoiesis, severe kidney or liver failure.



Possible side effect

Methotrexate is usually well tolerated but some patients may develop mouth sores, stomach upset, and low white blood counts. Methotrexate is known to be toxic to the liver, kidneys, lung and bone marrow. Blood tests should be done on a regular basis while treatment with this drug. Other adverse reactions may include headache, drowsiness and allergic reactions such as skin rash, itching, dizziness, and hair loss.



Drug interaction

Inform your doctor about all prescribed and over-the-counter medications, herbal products and food supplements you take and especially about NSAIDs such as ibuprofen (Motrin, Advil), diclofenac (Cataflam, Voltaren), naproxen (Aleve, Naprosyn), etodolac (Lodine), indomethacin (Indocin), meloxicam (Mobic), piroxicam (Feldene) as they increase Methotrexate toxicity); azathioprine (Imuran). Use of anti-gout drugs (allopurinol, colchicine, sulfinpirazon) requires correction of the dose. Inform your doctor also about chloramphenicol (Chloromycetin), hydroxychloroquine (Plaquenil, Quineprox), retinol, tretinoin (Retin-A), isotretinoin (Accutane), steroids (prednisone and others), sulfa drugs (Bactrim, Septra, Azulfidine), phenytoin (Dilantin), theophylline (Theobid, Theo-Dur, Elixophyllin, Slo-Bid), probenecid (Benemid), tetracycline (Brodspec, Panmycin, Sumycin, Tetracap), oral anti-diabetes drugs such as glipizide (Glucotrol), chlorpropamide (Diabinese), acetohexamide (Dymelor), glimepiride (Amaryl), or tolbutamide (Orinase), a penicillin antibiotics, salicylates (Dolobid, Salflex, Tricosal, Disalcid, Doan's Pills).



Missed dose

Consult your doctor if you miss a dose of this medicine.



Overdose

Contact your doctor immediately if you suspect overdose. Signs of overdose include nausea, vomiting, weakness, paleness, easy bruising or bleeding, mouth sores, black or bloody stools, coughing up blood, vomit similar to coffee grounds, decreased urination or anuria.



Storage

Store in a dry tight container away from sunlight at room temperature between 15-30 C (59-86 F) away from children and pets.



Disclaimer

We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.
Antibiotics

Antibiotics is one of most prescribed group of medications. Antibiotics are antibacterial (antimicrobial agents) that kills bacteria(bactericidal) or stop the growth of the bacteria(bacteriostatic action).

Antibiotics are used to treat bacterial infections and are not indicated for the viral infections. Currently there is a big variety of antibiotics available. All the antibiotics are divided into two main groups according to the action mechanism:

  • Antibiotics with bactericidal action(penicillins, cephalosporins, aminoglycoside)
  • Antibacterial with bacteriostatic action(macrolides, tetracyclines)

Penicillins and cephalospororins are the most prescribed group of antibiotics. They belong to half-synthetic beta lactam antibiotics. These antibiotics work by inhibiting the enzymes responsible for the production of peptidoglycan. Peptidoglycan is a biopolimer that is a main structural component of the bacterial cell wall. The blockage of peptidoglycan synthesis leads to the lysis of the microorganisms.

Another group of preparations are aminoglycosides. However, these antibiotics are prescribed in rare cases. The most of aminoglycosides possesses nephrotoxicity, ototoxicity and cab cause neuromuscular blockage. Bactericidal action of aminoglycosides is related to the interfering with the synthesis of proteins on the ribisomes in the microbial cells. When aminoglycosides are used with penicillins and cephalosporins the sinergism against gram-positive and gram-negative microorganisms is observed.

Among all bacteriostatic antibiotics macrolides and tetracyclines are the most indicated groups. Therapeutic effect of macrolides is associated with inhibiting the synthesis of proteins on the ribosomes in the microbial cell. As usual macrolides exert bacteriostatic action, however in high amounts are able to exert bactericidal action on some microorganisms. Besides antibacterial action, some macrolides possesses immunomodulatory and anti-inflammatory action.

Another group of bacteriostatic antibiotics are used less frequently as many microorganisms became resistant to the this type of antibiotics. Bacteriostatic effect of the tetracyclines is associated with inhibiting the synthesis of proteins. Tetracycline are indicated in clamydia infections, rickettsial disease, some zoonosis, severe acne.

Antibiotics are indicated and used only in the cases of the bacteria is sensitive to the antibiotics. There some specific tests like antibiogram that will help to determine the right antibiotic and corresponding dose.