Generic Prograf (Tacrolimus)
Prograf suppresses immune system of the body to avoid rejection of a transplanted heart, liver, or kidney.
Per Pills
0,5 mg x 10 pills
0,5 mg x 20 pills
0,5 mg x 30 pills
0,5 mg x 60 pills
0,5 mg x 90 pills
Per Pills
1 mg x 10 pills
1 mg x 20 pills
1 mg x 30 pills
1 mg x 60 pills
1 mg x 90 pills
Per Pills
5 mg x 10 pills
5 mg x 20 pills
Product Description
As mentioned, if two methoxymalonyl CoA molecules are substituted for two malonyl-CoA molecules, they will take place in module 7 and 8 C13 and Prpgrafand fkbA enzyme will Prograf this process. Pharmacogenetics and Genomics. Alcohol can make the side effects from tacrolimus worse. Prlgraf 8 March Your doctor will monitor you Prograaf and adjust Pfograf dose as needed. Using Prograf may increase your risk of developing serious infections or certain types of cancer, such as lymphoma or skin cancer. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Keep this medication in the container it came in, tightly closed, and out of reach of children. It has similar immunosuppressive properties to ciclosporinbut is much more potent. The antirejection tacrolimus healthcare providers have prescribed for more than 20 years. Ask your pharmacist any questions you have about refilling your prescription. A hat provides additional protection. It is also important information to carry with you in case of emergencies. The mean tacrolimus daily dose was 2. Because Prograf tacrolimus suppresses the immune system, it increases the risk of serious infections and cancer. Separate multiple e-mails with a. Save my selection. Do not take more or less of it or take it more often than prescribed by your doctor. Prograf is subject to eligibility requirements and Program terms and conditions. Some of the symptoms of an allergic reaction may include: shortness of breath wheezing or difficulty breathing swelling of the face, lips, tongue or other parts of the body rash, itching or hives on the skin. There is evidence to suggest that dosing patients based on rs genotype can result in faster and more frequent achievement of target tacrolimus levels. Tacrolimus was especially useful when given after thymectomy in combination with prednisone. African American and Hispanic patients who have had kidney transplants have an especially high risk of developing diabetes during their treatment with tacrolimus. Report unexplained nausea and vomiting that lasts more than 24 hours. In case of overdose, call the poison control helpline at Continue to take tacrolimus even if you feel well. July - Volume - Issue. Tacrolimus is predominantly eliminated via the faeces in form of its metabolites. You may need to read it again. Do not save this mixture for later use. Tacrolimus can only prevent rejection of your transplant as long as you are taking the medication. Do this even if there are no signs of discomfort or poisoning. Progeaf published: 01 May Reasonable care is taken to provide accurate Prgoraf at the time of creation. National Institutes of Health U. Get emergency medical help if you have signs of an allergic reaction to Prograf : hives ; difficult breathing; swelling of your face, lips, tongue, or throat. Call your healthcare provider for medical advice about side effects. Tacrolimus comes as a capsule, granules for oral suspension to be mixed with liquidan extended-release long acting capsule, and an extended-release tablet to take by mouth. Prograf oral granules must be mixed with water right before you take them. Do not take a double dose to make up for the dose you missed. In the majority of participants, it replaced prednisone as an immunosuppressive agent. The granules will not completely dissolve. Conversion is usually done using a dose ratio ofbut there is suggestion that ethnicity influences dosage adjustment and Asian patients may require higher doses to achieve target trough concentrations. In case of overdose, call the poison control helpline at Your healthcare provider should decide what medicine is right Prograr you. Your doctor may need to change Prograv doses of your medications or monitor you more carefully for side effects. If you have taken too much Porgraf Immediately telephone your doctor or the Poisons Information Centre telephone Progfaf 11 26 for advice, or go to Accident and Emergency at your nearest hospital. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective. However, you should not flush this medication down the toilet. How should this medicine be used? How should this medicine be used? What should I do if I forget a dose? Call your doctor if you have any unusual problems while you are taking this medication. Tacrolimus Astagraf XL, Envarsus XR, Prograf is used along with other medications to prevent rejection attack of a transplanted organ by the immune system of a person receiving the organ in people who have received a kidney transplant. After the cyclization, the pre-tacrolimus molecule goes through the post-synthase tailoring steps such as oxidation and S -adenosyl methionine. See Requirements. These growths can be internal or external, such as swollen glands in the neck, armpit, tonsil area, or Proggraf. All rights reserved. Ask your doctor if you have any questions about how much tacrolimus you should take. Visit www. Call your doctor right away if you have symptoms of a serious brain infection, such as a change in your mental state, problems Porgraf speech or walking, or decreased vision. Place 1 to 2 tablespoons 15 to 30 milliliters of water into a cup containing the granules. Symptoms of overdose may include: hives sleepiness nausea, vomiting, and diarrhea uncontrollable shaking of a part of the body, headache, confusion, imbalance, and extreme tiredness swelling of arms or legs fever or other signs of infection. Parents, legal guardians, and patients may also sign-up in person during a hospital stay, at a clinic appointment, or by visiting the UPMC Health Plan Connect Service and Sales Center at your local mall. Continue to take tacrolimus even if you feel well. You should be checked yearly for skin growths. If you have trouble remembering when to take your medicine, ask your pharmacist for some hints. Ganong 8 March Other details Because Prograf tacrolimus suppresses the immune system, it increases the risk of serious infections and cancer. Liver Transplant. Anti-thymocyte globulin Anti-lymphocyte globulin. Interactive Progra. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. Ptograf may need urgent medical attention. Do not assume that a swollen gland Probraf normal or a sign of infection. Take tacrolimus at the same time Pograf every day. All forms of tacrolimus are not equivalent and may not have the same dose or schedule. Other common side effects include: Tremors Diarrhea Loss of appetite Hair loss Insomnia Burning or tingling of the hands or feet Rare side effects include: Skin rash Vomiting Dizziness Anxiety Fever Chills Weakness Vision changes Chest pain Bruising or bleeding swelling of the feet or ankles Breathing trouble Constant hunger or thirst If any of these side effects continues or becomes bothersome, inform your doctor immediately. Tell your doctor if you experience any of the following and they worry you: tiredness, lack of energy stomach upset, including nausea feeling sickvomiting, loss of appetite, diarrhoea, stomach cramps tremor shaking headache feeling depressed sad sleeping difficulties blurred vision or sensitive to light muscle cramps, tenderness or weakness.
Common use

Prograf suppresses immune system and is used to prevent organ rejection after transplantation of heart, kidney, small bowel, bone marrow. Its active component is anhydrous tacrolimus. The drug binds to cytosolic protein (FKBP 12) and inhibits calcineurin hereby suppressing T-cell dependent immune response of the organism, formation of cytotoxic lymphocytes, proliferation of B cells depending on T-helpers, and formation of interleukin-2, -3 and Оі-interferon.

Dosage and direction

The daily dose of Prograf should be divided in two intakes separated by twelve hours. The capsules should be taken immediately after taking them out from the blister packs with full glass of water on an empty stomach, or at least one hour before or 2-3 hours after a meal. Fatty food decreases absorption of the medication. Correction of the dose is needed inpatients with serious liver impairment.


Risk of caner and especially skin cancer and infectious diseases increases due to immune suppressing effect of Prograf. Avoid exposing yourself to direct sun rays. Blood cell count, kidney and liver unction should be monitored on a regular basis while taking this medication. Diabetes may develop especially in Hispanic or African-American patients. Do not take the medicine with a grapefruit juice. This medication can appear in breast milk and transfer through placenta which can be harmful to a baby. Breastfeeding should be stopped while on Prograf. Inform your doctor if you have kidney or liver diseases, high blood pressure, or if you have taken cyclosporine (Neoral, Sandimmune, Gengraf) within the day before.


The preparation cannot be administered in patients hypersensitive to tacrolimus, other macrolides, or or hydrogenated castor oil.

Possible side effect

Side effects of Prograf are numerous and include arterial hypertension, hypotension, angina, stroke, tachycardia, arrhythmia, diarrhea, nausea, vomiting, abdominal pain, change of liver transaminases activity, constipation, anemia, easy bruising and bleeding, changes in clotting, kidney disorders and failure, hyperglycemia, hyperpotessemia, diabetes, seizures, pain in joints, miastenia, tremor, headache, vision changes, dizziness, depression, mental confusion, hallucinations, difficulty breathing, allergy, achne, photosensitivity, high risk of tumor formation, high body temperature, swelling of extremities, baldness. In case of bothersome and serious side effects seek immediate medical attention.

Drug interaction

Prograf may slow down metabolism of Cyclosporine (Neoral, Sandimmune, Gengraf) thus increasing its toxicity. As Prograf is metabolized by cytochrome CYP 3A4, a concomitant use of medications affecting or being metabolized by this cytochrome may change Prograf levels in the blood (for example testosterone, cortisone). Tacrolimus binds to proteins of blood serum and and may change (mutually) effects of the medications with high affinity to serum proteins such as peroral anticoagulants, diabetic drugs or NSAIDs. Concomitant use of Prograf with neurotoxic or nephrotoxic medication may increase toxicity (aminoglycosides, inhibitors of DNA gyrase, vancomycin, co-trimoxazole, NSAIDs, ganciclovir or acyclovir). Avoid co-administration of Prograf with potassium-saving diuretics of medicines which contain potassium to avoid hyperpotassemia (Dyazide, Maxzide, amiloride, Moduretic, and spironolactone, Aldactone). Effects of vaccination may be decreased and use of live attenuated vaccines should be avoided. Inform your doctor about all drugs and herbal products you are taking.

Missed dose

Never take a double dose of this medication. If it is almost time of the next dose just skip the missed portion and continue to take the medicine according to the schedule.


In cases of accidental Prograf overdose the following symptoms were described: tremor, headache, nausea, vomiting, infection, rash, lethargy, increased urea nitrogen in blood and increased serum concentrations of creatinine and alanine transaminase (ALT).


Prograf should be stored at room temperature between 15-30 C (59-86 F).


We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.

Antibiotics is one of most prescribed group of medications. Antibiotics are antibacterial (antimicrobial agents) that kills bacteria(bactericidal) or stop the growth of the bacteria(bacteriostatic action).

Antibiotics are used to treat bacterial infections and are not indicated for the viral infections. Currently there is a big variety of antibiotics available. All the antibiotics are divided into two main groups according to the action mechanism:

  • Antibiotics with bactericidal action(penicillins, cephalosporins, aminoglycoside)
  • Antibacterial with bacteriostatic action(macrolides, tetracyclines)

Penicillins and cephalospororins are the most prescribed group of antibiotics. They belong to half-synthetic beta lactam antibiotics. These antibiotics work by inhibiting the enzymes responsible for the production of peptidoglycan. Peptidoglycan is a biopolimer that is a main structural component of the bacterial cell wall. The blockage of peptidoglycan synthesis leads to the lysis of the microorganisms.

Another group of preparations are aminoglycosides. However, these antibiotics are prescribed in rare cases. The most of aminoglycosides possesses nephrotoxicity, ototoxicity and cab cause neuromuscular blockage. Bactericidal action of aminoglycosides is related to the interfering with the synthesis of proteins on the ribisomes in the microbial cells. When aminoglycosides are used with penicillins and cephalosporins the sinergism against gram-positive and gram-negative microorganisms is observed.

Among all bacteriostatic antibiotics macrolides and tetracyclines are the most indicated groups. Therapeutic effect of macrolides is associated with inhibiting the synthesis of proteins on the ribosomes in the microbial cell. As usual macrolides exert bacteriostatic action, however in high amounts are able to exert bactericidal action on some microorganisms. Besides antibacterial action, some macrolides possesses immunomodulatory and anti-inflammatory action.

Another group of bacteriostatic antibiotics are used less frequently as many microorganisms became resistant to the this type of antibiotics. Bacteriostatic effect of the tetracyclines is associated with inhibiting the synthesis of proteins. Tetracycline are indicated in clamydia infections, rickettsial disease, some zoonosis, severe acne.

Antibiotics are indicated and used only in the cases of the bacteria is sensitive to the antibiotics. There some specific tests like antibiogram that will help to determine the right antibiotic and corresponding dose.